Range Description: The species is present in the Mediterranean region (southern Europe, western Asia and northern Africa), especially on the western side (e.g. Category: cosmetic ingredient for skin conditioning. Recommendation for globularia alypum leaf extract usage levels up to: not for fragrance use. Globularia alypum methanolic extract improves burn wound healing process and inflammation in rats and possesses antibacterial and.

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Myorelaxant and spasmalytic effects of Globularia alypum L. Physiopathology of anabolic androgenic steroids abuse. Articles with ‘species’ microformats All stub articles. However, daily clinical examination showed the appearance of liquid stools from D 5 to D 25 that were more pronounced in female than in male rats. Thus, this study confirms its glpbularia use, however further more precise studies are needed for future clinical application. Hence, this work has been performed to evaluate the toxicity of the drug in animals.

The calibration curve was linear with a correlation coefficient of 0. Feb, [Retrieved on Nov 24]. Globulariaceae is a widely growing shrub in the Mediterranean area known for its uses in popular medicine for several properties: Oxandrolone in the treatment of HIV-associated weight loss in men: Support Center Support Center. Lipids and proteins were, respectively, measured by the sulfovanillic technique and the refractometric method.


During the treatment period, a control group of 10 male rats weighing A total of alypu compounds were identified. You can help Wikipedia by expanding it.

globularia alypum leaf extract

Approximately 50 g of leaf material was ground in a blender with 50 ml of distilled water for 3 min. Histological aljpum of gastric and intestinal mucosa was found strictly normal in all studied groups. Quantification of globularin Globularin, a principal iridoid glucosid present in G.

Harpagoside and globularin were, respectively, eluted at 8. Globulariz examination at this level revealed a thinning down of the esophageal wall and an atrophy of the muscular coat. This active spermatogenesis induction may suggest that the plant extract could contain androgenic active substances responsible of the recorded active spermatogenesis.

The determination of the acute toxicity of G.

During the treatment period, the animals, maintained by groups of 10 in Macrolon cages It has notably not been observed any loss of substance nor inflammatory infiltrate or lymphoid hyperplasia [ Figure 4c ]. At day D 16all the animals were killed and the testis of experimental animals were removed for histological examination. After drying in air, the leaves were used to prepare aqueous extract using water.

Globularia alypum L.

Histological examination of this organ showed the existence of a pronounced thinning of pulmonary arteriolar wall meaning the presence of histological grades I gllobularia II pulmonary hypertension PHT [ Figure 4a ].


Erythrocytes and leukocytes were determined with a Leuco-ery-counter B.

Statistical analysis of the results were performed by using Student’s t -test. InSkim et al. However, the most important finding of the study was the recorded active spermatogenesis that was induced by reiterated administrations of the drug that could suggest that G.

Biochemical investigations Concentrations of blood glucose, cholesterol and triglycerides were determined by enzymatic methods Sera Pak Kits, Ames, Italia.

Balansard J, Delphant J.

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The drug also induced at this level a vascular congestion, an important lymphoid hyperplasia, and a dystrophic dilatation of pulmonary alveoli with nearly the same importance in all male and female treated animals.

Alypu performance liquid chromatography analysis of globularin in Globularia alypum L. In other projects Wikimedia Commons Wikispecies. Androgens, corticosteroids and erythropoiesis. For the extinct genus of sea snails, see Globularia.