J Neurol Sci. Jan 21;(1) Clinical diagnosis in Karwinskia humboldtiana polyneuropathy. Martínez HR(1), Bermudez MV, Rangel-Guerra RA. Toxicon. May;53(6) doi: /n Karwinskia humboldtiana (buckthorn) fruit causes central nervous system damage during. Karwinskia humboldtiana. Karwinskia humboldtiana (Schult.) Zucc. Coyotillo, Humboldt Coyotillo. Rhamnaceae (Buckthorn Family). Synonym(s).

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Despite its toxic properties, parts of the coyotillo plant was used for medicinal purposes and, perhaps, even as starvation food by one group.

In two of these cases, a sural nerve biopsy revealed a segmental demyelination with swelling and phagocytic chambers in Schwann humbildtiana and without lymphocytic infiltration. Karwinskia humboldtiana fruit Kh causes a neurological disorder weeks after ingestion, characterized by flaccid, symmetrical, ascending paralysis, similar to the Guillain-Barre syndrome.

However, the leaves and the fruit, especially the seed inside the exocarp contain deadly neurotoxins.

University of Texas Press. From Wikipedia, the free encyclopedia. In other projects Wikimedia Commons Wikispecies. This Rhamnaceae article is a stub.

Karwinskia humboldtianacommonly known as coyotillocacachila or Humboldt coyotillois a species of flowering shrub or small tree in the buckthorn hjmboldtiana, Rhamnaceae.

Karwinskia humboldtiana – Wikipedia

The fruit is the most poisonous part of the Coyotillo plant, or, at least the karwinskoa inside the fruit. Therefore it takes weeks for the animal to show symptoms from coyotillo foliage consumption. These humbboldtiana had a symmetric motor polyneuropathy with humoldtiana absence of tendon reflexes and no sensory signs or cranial nerve involvement.

There is a curious and telling reference to coyotillo use by the Tarahumara. Spasms and paralysis in the extremities are the first observable symptoms of coyotillo poisoning, which often spreads to affect breathing or liver function, ending in death. However, he does note that a tincture of the leaves was used as an anticonvulsive for treating paralysis from tetanus, until the muscles relax. The plant was apparently more useful as a medicine.

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In our present work we fed the ground Kh fruit to Karwinskix rats and samples of brain, cerebellum, and pons were embedded in paraffin. The Tarahumara crushed coyotillo bark to prepare a tea that was ingested for fevers. Coyotillo krwinskia near the Pecos River.

Small wonder so many children in Mexico are poisoned by this common and deadly shrub. The presence of Karwinskia humboldtiana toxins in blood were determined by thin layer chromatography. Karwinskia humboldtiana Scientific classification Kingdom: The literature is replete with examples of coyotillo poisoning in both livestock and humans.

The medical and veterinary literature is fuzzy about whether the seed is poisonous and the sweet pulp is harmless, or they are both poisonous. Journal of Neurological Science 1: In six cases, T Karwinskia humboldtiana toxin was detected.

The Tepehuan also report using the fruit as a starvation food.

New York, New York: However, consumption of fruit is much more deadly. We present our experience in the clinical diagnosis of Karwinskia humboldtiana polyneuropathy, as confirmed by karwknskia detection in blood. Coyotillo is a small, evergreen shrub with deep green, almost glossy and distinctively veined leaves that grow opposite each other along the stem.

However, it karwinskix takes days or even weeks after consumption for the symptoms to manifest. Algonquin Books of Chapel Hill.

It is native to southern and western Texas in the United States [2] as well as much of Mexico. All six cases survived, with complete recovery in five. We designed an open trial at the Pediatric Neurology service and included all cases with acute ascending paralysis that were admitted to our hospital in the last two years. Indeed, the Tepehuan boil the bark for several hours and ingest the resultant tea for fevers, identical uses to the Tarahumara that the ethnographer duly noted Pennington ; My concern is that the relaxation might well be permanent.


Histopathological changes were evaluated in the CNS through the humboldhiana stages of the karwinslia and comparison to a control group.

Tragically, children are its most common victims. Although many victims recover completely, in serious cases they are left quadriplegic. Clinical diagnosis in poisoned humans may be difficult if no evidence of kadwinskia fruit ingestion is available.

This page was last edited on 25 Augustat Views Read Edit View history.

Intoxication with buckthorn (Karwinskia humboldtiana): report of three siblings.

In this polyneuropathy the lesion demyelization in peripheral nerves has been described in several animal species, both in acute and in chronic intoxication. Their Environment and Material Culture. The availability of toxin detection in blood samples allows the clinician to establish an accurate diagnosis and should be included in the study of children with polyradiculoneuropathy, especially in countries where this poisonous plant grows.

It is a widespread component of shrubby landscape on the southwestern edge of the Edwards Plateau, and its range extends into the south Texas Plains and across the Trans-Pecos, especially on soils derived from limestone. Additionally, a cooked potion of the leaves was applied externally to infected wounds Martinez Coyotillo contains potent neurotoxins, the most prominent of which are tullidinol toxin T and peroxisomicine toxin T It only takes 0. karwinsiia