Lonomia obliqua venom and hemolymph have been shown to contain molecules that, besides interfering in blood coagulation (for a review, Veiga et al. ). Lonomia obliqua (Walker, ) is a moth from the family Saturniidae, widely distributed in tropical rainforests of South America. In its larval stage (caterpillar) it . Rev Assoc Med Bras (). May-Jun;61(3) doi: / Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis .

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But, despite the decrease in NO production, the venom acts inducing proliferation of cells by other cellular mechanisms. In vitro hemolityc activity of Lonomia obliqua caterpillar bristle extract on human and Wistar rat erytrocytes.

Despite an improvement in symptoms, the haematocrit initially continued to fall These results show that the effects of the venom depend on the cell type tested. This reaction occurs only when the mitochondrial reductase enzymes are active in living cells; thus, the conversion of MTT to formazam crystals is used to determine viable cells.

This article has been cited by other articles in PMC. However, the venom decreases the viability of V Chinese hamster fibroblasts. The LD 50 of the Lonomia venom is 0.

MTT analyses indicate that L. A central line was inserted and after the initial haemodialysis session she was given 10 ampoules of anti-lonomic horse serum.


Lonomia – Wikipedia

Intracerebral haemorrhage after contact with Lonomia caterpillars. This mechanism also occurs lonomoa normal cells, in which proliferation is well regulated, which does not occur in tumor cells.

Four days before, she had started to present hematuria. Losac, a factor X activator from Lonomia obliqua bristle extract: Short daily dialysis for 2 h per day was continued for the next three consecutive days.

Lonomia obliqua Walker (Lepidoptera: Saturniidae): hemostasis implications.

Purification and characterization of an anti-apoptotic protein isolated from Lonomia obliqua hemolymph. The decrease in NO production induced by the venom does not completely oboiqua the proliferative effect of the venom, because, as shown in Fig. Latest Most Read Most Cited Screening questions for the diagnosis of restless legs syndrome in hemodialysis. CT-scan imaging revealed multiple intracerebral hemorrhages.

Nitric oxide production Previous studies showed that Lopap, a protein purified from the venom of L. The increase in cell number could obliqja clearly observed under light microscopy Fig.

Lonomia obliqua – Wikipedia tiếng Việt

She was eupneic and afebrile. Its venom has been the subject of numerous medical studies. Culture of mammalian cells represent a major resource for producing high-value bio-therapeutic obliaua Wurmwhich includes monoclonal antibodies Rycyzyn et al.


Acute kidney injury associated with lymphangitic carcinomatosis. We express special thanks to Dr. Toxin Involvement and Molecular Approach”. The genus Lonomia is a moderate-sized group of fairly cryptic saturniid moths from South Americafamous not for the adults, but for their highly venomous caterpillarswhich are responsible for a few deaths each year, [1] especially in southern Braziland the subject of hundreds of published medical studies.

Cell counting Lonomiw venom treatment of the UMG lnomia line, medium was removed, cells were washed in PBS and detached with trypsin 0. The caterpillar has been responsible for many human deaths, especially in southern Brazil.

Lojomia from ” https: Chinese hamster fibroblasts V and human colorectal cancer cell line HT More on this topic Acute kidney injury among paediatric emergency room admissions in a tertiary hospital in South West Nigeria: Receive exclusive offers and updates from Oxford Academic. Hematoma and gangrene -like symptoms manifested, spreading throughout the body, eventually causing massive blood leakage into the brain and, in several cases, death.